Secondry Anti-Tuberculosis Drugs

drug-resistant tuberculosis and group 5 anti-tuberculosis drugs

Clinical development of anti-tuberculosis drugs.

In the clinical development of new anti-tuberculosis drugs, the most important step is efficient Phase II studies to show whether the drug is likely to be able to shorten treatment and with what other drugs it has the greatest sterilizing activity. The use of non-linear mixed effects modelling applied to serial sputum cfu counts appears to be the most effective technique, but we know little abo...

New anti-tuberculosis agents amongst known drugs.

Mycobacterium tuberculosis has an on-going impact on global public health and new therapeutics to treat tuberculosis are urgently required. The emergence of drug resistant tuberculosis poses a serious threat to the control of this pathogen, and the development of drugs that are active against the resistant strains is vital. A medium-throughput assay using the Alamar Blue reagent was set-up to i...

Availability of anti-tuberculosis drugs in Europe.

Acknowledgements: The members of the SMIRA Group were: C. Piersimoni (Ospedali Riuniti, Ancona, Italy); P. Lorenzetti (Ospedale di Aosta, Aosta, Italy); D. Costa (Policlinico di Bari, Bari, Italy); A. Grimaldi (Ospedale Fallacara, Triggiano, Bari, Italy); M. Arosio and A. Goglio (Ospedali Riuniti, Bergamo, Italy); C. Mazza and L. Squintani (Ospedale Maggiore, Bologna, Italy); C. Larcher and E. ...

Anti-tuberculosis drugs and liver toxicity.